MODR Seminar – Dr. Emily Day – Western University
Dec 5, 2024
12:00PM to 1:00PM
Date/Time
Date(s) - 05/12/2024
12:00 pm - 1:00 pm
The macrophage mitochondrial metabolite, itaconate, induces GDF15 expression through NRF2 and ATF4
Emily completed her Honors Bachelor of Sciences in Biochemistry and Biomedical Sciences at McMaster University in 2014. She then continued at McMaster University and completed her PhD in Medical Sciences under the supervision of Prof. Gregory Steinberg. Emily’s PhD examined the effects of glucose lowering medications on obesity and atherosclerosis with a special focus on the contributions of macrophages. Emily then moved to Trinity College Dublin where she held a Banting Post-Doctoral Fellowship in the lab of Prof. Luke O’Neill and examined the role of immune cell mitochondrial metabolism on immune cell function and whole-body metabolism. She has now started her own lab at Western University in the department of Physiology and Pharmacology studying immune cell stress responses in inflammation and metabolic disease.
Learning Objectives:
- Understand how TCA cycle disruption in macrophages contributes to cytokine signaling
- Examine the mechanisms behind itaconate induced GDF15
- Examine the role of Itaconate in body weight regulation
This is a hybrid event. Please register for zoom link.