Date/Time
Date(s) - 02/05/2024
12:00 pm - 1:00 pm
Microbiome and MASLD: Origins and Future Directions
Nikhil Pai is an Associate Professor of Pediatrics at McMaster University, and Staff Physician through the Division of Pediatric Gastroenterology at McMaster Children’s Hospital. He completed his medical training at McMaster University, the Hospital for Sick Children (University of Toronto), Boston Children’s Hospital (Harvard Medical School, and Massachusetts General Hospital.
Dr. Pai’s research focuses on the role of nutritional science and microbial therapeutics in pediatric gastroenterology, including through the use of fecal microbiota transplant in pediatric inflammatory bowel disease (IBD). He leads an active research group (Pai Lab), and is currently leading a CIHR-funded trial on the role of prebiotic therapies in pediatric MASLD.
In July of this year, Dr. Pai will be joining the Perelman School of Medicine at the University of Pennsylvania as an Associate Professor, and the Children’s Hospital of Philadelphia (CHOP) as a Clinician-Scientist within the Division of Gastroenterology, Hepatology & Nutrition. He will maintain his appointment as a part-time Associate Professor with McMaster University.
Learning Objectives:
- Review the connection between microbial dysbiosis and the pathophysiology of metabolism-associated steatitic liver disease (MASLD).
- Share evidence for microbial interactions in MASLD.
- Discuss potential microbiota-based treatments for MASLD.
Contribution of Rare Coding Variants to Complex Trait Heritability
Nazia Pathan is a final year PhD candidate in the Medical Sciences program, with interest in using large biobanks to study the impact of genetics on health and diseases. Beyond her PhD studies, she is a sessional faculty at B.Tech, McMaster University, Chairs Bioinformatics meetings for trainees at the Genetics Molecular and Epidemiology Lab, and a ClinGen Biocurator, which is an international group studying the validity of genes for cardiac conduction diseases.
Learning Objectives:
- Understanding the significance of rare coding variants in the human genome
- Obtain an overview of a genetics model, RARity, for estimating the contributions of rare variants to complex trait heritability.
- Discuss versatile utility of RARity
This is a hybrid event. Please join us in person in HSC 1A5. Please register for zoom link here.